Price change dependent on selecting two different options

[NuttyKevin]

I'm looking for a new shopping cart for a new website, one of the features which is essential is that there are price changes based on selecting 2 or more options, for example, if a customer chooses a size, then chooses the a quantity from drop down selection boxes, the price would then change in the product display, is this something that can be done in Virtuemart, or extensions available?
I currently use Opencart which I have found brilliant, but looking to change to a different shopping cart which can offer more.
Any help/comments would be appreciated